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A study of multinucleated giant cells in esophageal cancer.
Wang, Hui; Zhou, Junjie; Li, Jun; Geng, Yiqun; Meng, Pei; Ma, Changchun; Zhu, Ziqi; Zhang, Weifeng; Hong, Liangli; Quan, Yan; Wei, Jiacong; Huang, Qiongyi; Zhou, You; Su, Zuoqing; Zhu, Xiaoqing; Chen, Chuangzhen; Chen, Shaobin; Gu, Jiang.
Affiliation
  • Wang H; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China.
  • Zhou J; Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Li J; Division of Hepatobiliary and Pancreatic Surgery, the University of Hong Kong -Shenzhen Hospital, Shenzhen, Guangdong, China.
  • Geng Y; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China.
  • Meng P; Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Holland, the Netherlands.
  • Ma C; Department of Radiation Oncology, Affiliated Cancer Hospital, Shantou University Medical College, Shantou, Guangdong, China.
  • Zhu Z; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China.
  • Zhang W; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China.
  • Hong L; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China.
  • Quan Y; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China.
  • Wei J; Department of Pathology, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China.
  • Huang Q; Department of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
  • Zhou Y; Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Su Z; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China.
  • Zhu X; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China.
  • Chen C; Department of Radiation Oncology, Affiliated Cancer Hospital, Shantou University Medical College, Shantou, Guangdong, China.
  • Chen S; Department of Thoracic Surgery, Affiliated Cancer Hospital, Shantou University Medical College, Shantou, Guangdong, China.
  • Gu J; Provincial Key Laboratory of Molecular Pathology and Personalized Medicine, Center of Collaborative and Creative Center, Department of Pathology and Pathophysiology, Shantou University Medical College, Shantou, Guangdong, China; Jinxin Research Institute for Reproductive Medicine and Genetics, Cheng
Clin Immunol ; 222: 108600, 2021 01.
Article in En | MEDLINE | ID: mdl-33197619
ABSTRACT

OBJECTIVES:

To evaluate the occurrence, abundance, distribution, nature and clinical significance of multinucleated giant cell (MGC) in esophageal cancer. MATERIALS AND

METHODS:

MGCs were examined with conventional pathology, immunohistochemistry and immunofluorescence in 107 esophageal cancer tissues. The findings were correlated to pathological diagnosis and clinical behavior of the cancers.

RESULTS:

MGCs were identified in 31.7% (34/107) of the cases. MGCs were positive for CD11c, CD11b, CD32, CD16, HLA-DR and MMP9, and negative for CD163, CD206 and CD64 giving a molecular profile of proinflammatory M1 but not immunosuppressive M2. MGCs were significantly related to decreased lymph node metastasis (p = 0.011), low pTNM stage (p = 0.044), favorable survival (p = 0.04), squamous cell cancer type rather than other histopathological subtypes (p = 0.020) and associated to better differentiation (p = 0.063).

CONCLUSIONS:

MGCs belong to M1 macrophage and perform phagocytosis and scavenging of cancer cells that would benefit patients' survival and could serve as a prognostic marker.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Esophageal Neoplasms / Giant Cells / Esophagus / Macrophages Type of study: Diagnostic_studies / Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Esophageal Neoplasms / Giant Cells / Esophagus / Macrophages Type of study: Diagnostic_studies / Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: China