Chimeric antigen receptor (CAR) natural killer (NK)-cell therapy: leveraging the power of innate immunity.

Rafei, Hind; Daher, May; Rezvani, Katayoun

Rafei, Hind; Daher, May; Rezvani, Katayoun.

Affiliation

Rafei H; Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Daher M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rezvani K; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Br J Haematol ; 193(2): 216-230, 2021 04.

Article in En | MEDLINE | ID: mdl-33216984

Subject(s)

Immunity, Innate/drug effects; Immunotherapy, Adoptive/adverse effects; Killer Cells, Natural/immunology; Neoplasms/therapy; Receptors, Chimeric Antigen/therapeutic use; Allografts; Clinical Trials as Topic; Cytokine Release Syndrome/chemically induced; Genetic Engineering/methods; Graft vs Host Disease/chemically induced; Humans; Immunotherapy/methods; Immunotherapy, Adoptive/economics; Immunotherapy, Adoptive/methods; Induced Pluripotent Stem Cells/immunology; Induced Pluripotent Stem Cells/transplantation; Neurotoxicity Syndromes/etiology; Receptors, Chimeric Antigen/administration & dosage; Safety; Time-to-Treatment/statistics & numerical data

Key words

CAR-NK cells; adoptive cell transfer; cancer; chimeric antigen receptor natural killer cells; genetic engineering; natural killer cell therapy; natural killer cells

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Killer Cells, Natural / Immunotherapy, Adoptive / Receptors, Chimeric Antigen / Immunity, Innate / Neoplasms Type of study: Etiology_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2021 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google