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A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy.
Manzo, Giorgia; Hind, Charlotte K; Ferguson, Philip M; Amison, Richard T; Hodgson-Casson, Alice C; Ciazynska, Katarzyna A; Weller, Bethany J; Clarke, Maria; Lam, Carolyn; Man, Rico C H; Shaughnessy, Blaze G O'; Clifford, Melanie; Bui, Tam T; Drake, Alex F; Atkinson, R Andrew; Lam, Jenny K W; Pitchford, Simon C; Page, Clive P; Phoenix, David A; Lorenz, Christian D; Sutton, J Mark; Mason, A James.
Affiliation
  • Manzo G; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Hind CK; Technology Development Group, National Infection Service, Public Health England, Salisbury, UK.
  • Ferguson PM; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Amison RT; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Hodgson-Casson AC; Sackler Institute of Pulmonary Pharmacology, King's College London, London, UK.
  • Ciazynska KA; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Weller BJ; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Clarke M; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Lam C; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Man RCH; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Shaughnessy BGO; Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
  • Clifford M; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Bui TT; Sackler Institute of Pulmonary Pharmacology, King's College London, London, UK.
  • Drake AF; Technology Development Group, National Infection Service, Public Health England, Salisbury, UK.
  • Atkinson RA; Centre for Biomolecular Spectroscopy and Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, London, SE1 1UL, UK.
  • Lam JKW; Centre for Biomolecular Spectroscopy and Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, London, SE1 1UL, UK.
  • Pitchford SC; Centre for Biomolecular Spectroscopy and Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, London, SE1 1UL, UK.
  • Page CP; Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
  • Phoenix DA; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Lorenz CD; Sackler Institute of Pulmonary Pharmacology, King's College London, London, UK.
  • Sutton JM; Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK.
  • Mason AJ; Sackler Institute of Pulmonary Pharmacology, King's College London, London, UK.
Commun Biol ; 3(1): 697, 2020 11 27.
Article in En | MEDLINE | ID: mdl-33247193
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fish Proteins / Pore Forming Cytotoxic Proteins / Lung Diseases / Anti-Bacterial Agents Limits: Animals / Humans / Male Language: En Journal: Commun Biol Year: 2020 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fish Proteins / Pore Forming Cytotoxic Proteins / Lung Diseases / Anti-Bacterial Agents Limits: Animals / Humans / Male Language: En Journal: Commun Biol Year: 2020 Type: Article Affiliation country: United kingdom