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Physiologically-Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective.
Heimbach, Tycho; Chen, Yuan; Chen, Jun; Dixit, Vaishali; Parrott, Neil; Peters, Sheila Annie; Poggesi, Italo; Sharma, Pradeep; Snoeys, Jan; Shebley, Mohamad; Tai, Guoying; Tse, Susanna; Upreti, Vijay V; Wang, Ying-Hong; Tsai, Alice; Xia, Binfeng; Zheng, Ming; Zhu, Andy Z X; Hall, Stephen.
Affiliation
  • Heimbach T; Pharmaceutical Sciences, Merck & Co., Inc, Rahway, New Jersey, USA.
  • Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, California, USA.
  • Chen J; Clinical Pharmacology, Alkermes Inc, Waltham, Massachusetts, USA.
  • Dixit V; Drug Metabolism and Pharmacokinetics, Kymera Therapeutics, Watertown, Massachusetts, USA.
  • Parrott N; Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
  • Peters SA; Translational Medicine, Merck Healthcare KGaA, Darmstadt, Germany.
  • Poggesi I; Clinical Pharmacology and Pharmacometrics, Janssen, Milan, Italy.
  • Sharma P; Clinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
  • Snoeys J; Department of Drug Metabolism and Pharmacokinetics, Janssen R&D, Beerse, Belgium.
  • Shebley M; Clinical Pharmacology and Pharmacometrics, AbbVie Inc, North Chicago, Illinois, USA.
  • Tai G; Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Plc, Collegeville, Pennsylvania, USA.
  • Tse S; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc, Groton, Connecticut, USA.
  • Upreti VV; Clinical Pharmacology, Modeling & Simulation, Amgen Inc, South San Francisco, California, USA.
  • Wang YH; Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co, Inc, Kenilworth, New Jersey, USA.
  • Tsai A; Department of Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals Inc, Boston, Massachusetts, USA.
  • Xia B; PK/PD Group, Pharmacokinetics, Dynamics and Metabolism, Sanofi, Bridgewater, New Jersey, USA.
  • Zheng M; Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Zhu AZX; Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International, Co, Cambridge, Massachusetts, USA.
  • Hall S; Department of Drug Disposition, Lilly, Indianapolis, Indiana, USA.
Clin Pharmacol Ther ; 110(2): 297-310, 2021 08.
Article in En | MEDLINE | ID: mdl-33270249
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Drug Industry / Kidney Diseases / Liver Diseases / Models, Biological Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2021 Type: Article Affiliation country: United States
Fulltext
Print
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PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacokinetics / Drug Industry / Kidney Diseases / Liver Diseases / Models, Biological Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Pharmacol Ther Year: 2021 Type: Article Affiliation country: United States