Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.

Pallan, Pradeep S; Lybrand, Terry P; Schlegel, Mark K; Harp, Joel M; Jahns, Hartmut; Manoharan, Muthiah; Egli, Martin

Pallan, Pradeep S; Lybrand, Terry P; Schlegel, Mark K; Harp, Joel M; Jahns, Hartmut; Manoharan, Muthiah; Egli, Martin.

Affiliation

Schlegel MK; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
Jahns H; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.
Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States.

Biochemistry ; 59(49): 4627-4637, 2020 12 15.

Article in En | MEDLINE | ID: mdl-33275419

Subject(s)

Nucleotide Motifs; RNA/chemistry; Crystallography, X-Ray; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Nucleic Acid Conformation; Phosphates/chemistry; RNA/genetics; RNA Stability; RNA, Bacterial/chemistry; RNA, Bacterial/genetics; RNA, Ribosomal, 23S/chemistry; RNA, Ribosomal, 23S/genetics; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA / Nucleotide Motifs Type of study: Etiology_studies Language: En Journal: Biochemistry Year: 2020 Type: Article

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