Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.
Trends Biochem Sci
; 46(4): 258-269, 2021 04.
Article
in En
| MEDLINE
| ID: mdl-33308996
ABSTRACT
Chromatin functions are influenced by the addition, removal, and recognition of histone post-translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone proteins can function as signaling molecules by mediating protein-protein interactions. Fueled by the identification of novel ubiquitin and UBL sites and the characterization of the writers, erasers, and readers, the breadth of chromatin functions associated with ubiquitin signaling is emerging. Here, we highlight recently appreciated roles for histone ubiquitination in DNA methylation control, PTM crosstalk, nucleosome structure, and phase separation. We also discuss the expanding diversity and functions associated with histone UBL modifications. We conclude with a look toward the future and pose key questions that will drive continued discovery at the interface of epigenetics and ubiquitin signaling.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatin
/
Histone Code
Type of study:
Prognostic_studies
Language:
En
Journal:
Trends Biochem Sci
Year:
2021
Type:
Article
Affiliation country:
United States