Hydrogen sulfide donors prevent lipopolysaccharide-induced airway hyperreactivity in an in vitro model of chronic inflammation in mice.

Karaman, Yasemin; Kaya-Yasar, Yesim; Bozkurt, T Emrah; Sahin-Erdemli, Inci

Karaman, Yasemin; Kaya-Yasar, Yesim; Bozkurt, T Emrah; Sahin-Erdemli, Inci.

Affiliation

Karaman Y; Faculty of Pharmacy, Department of Pharmacology, Hacettepe University, Ankara, Turkey.
Kaya-Yasar Y; Faculty of Pharmacy, Department of Pharmacology, Karadeniz Technical University, Trabzon, Turkey.
Bozkurt TE; Faculty of Pharmacy, Department of Pharmacology, Hacettepe University, Ankara, Turkey.
Sahin-Erdemli I; Faculty of Pharmacy, Department of Pharmacology, Hacettepe University, Ankara, Turkey.

Basic Clin Pharmacol Toxicol ; 128(5): 652-660, 2021 May.

Article in En | MEDLINE | ID: mdl-33369105

Subject(s)

Asthma/drug therapy; Hydrogen Sulfide/pharmacology; Morpholines/pharmacology; Organothiophosphorus Compounds/pharmacology; Sulfides/pharmacology; Animals; Asthma/immunology; Asthma/pathology; Disease Models, Animal; Humans; Inflammation/drug therapy; Inflammation/immunology; Inflammation/pathology; Interleukin-1beta/metabolism; Interleukin-6/metabolism; Lipopolysaccharides/administration & dosage; Lipopolysaccharides/immunology; Lung/drug effects; Lung/immunology; Lung/pathology; Male; Mice; Mice, Inbred BALB C; Morpholines/therapeutic use; Organothiophosphorus Compounds/therapeutic use; Sulfides/therapeutic use; Tumor Necrosis Factor-alpha/metabolism

Key words

AP39; GYY4137; airway hyperreactivity; airway inflammation; hydrogen sulfide

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organothiophosphorus Compounds / Asthma / Sulfides / Morpholines / Hydrogen Sulfide Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Basic Clin Pharmacol Toxicol Journal subject: FARMACOLOGIA / TOXICOLOGIA Year: 2021 Type: Article Affiliation country: Turkey

Fulltext

XML

PubMed Links

Search on Google