Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.

Hui, Chun Kiu; Dedkova, Elena N; Montgomery, Claire; Cortopassi, Gino

Hui, Chun Kiu; Dedkova, Elena N; Montgomery, Claire; Cortopassi, Gino.

Affiliation

Hui CK; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Dedkova EN; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Montgomery C; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Cortopassi G; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

Hum Mol Genet ; 29(24): 3954-3965, 2021 02 25.

Article in En | MEDLINE | ID: mdl-33432356

Subject(s)

Brain/physiology; Dimethyl Fumarate/pharmacology; Friedreich Ataxia/drug therapy; Gene Expression Regulation/drug effects; Mitochondria/physiology; Mitochondrial Proteins/metabolism; Muscles/physiology; Animals; Brain/drug effects; Dose-Response Relationship, Drug; Friedreich Ataxia/metabolism; Friedreich Ataxia/pathology; Immunosuppressive Agents/pharmacology; Mice; Mice, Inbred C57BL; Mitochondria/drug effects; Mitochondrial Proteins/genetics; Muscles/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Friedreich Ataxia / Gene Expression Regulation / Mitochondrial Proteins / Dimethyl Fumarate / Mitochondria / Muscles Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2021 Type: Article Affiliation country: United States

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