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Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays.
Gupta, Yash; Maciorowski, Dawid; Zak, Samantha E; Jones, Krysten A; Kathayat, Rahul S; Azizi, Saara-Anne; Mathur, Raman; Pearce, Catherine M; Ilc, David J; Husein, Hamza; Herbert, Andrew S; Bharti, Ajay; Rathi, Brijesh; Durvasula, Ravi; Becker, Daniel P; Dickinson, Bryan C; Dye, John M; Kempaiah, Prakasha.
Affiliation
  • Gupta Y; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA.
  • Maciorowski D; Loyola University Chicago, Chicago, IL, USA.
  • Zak SE; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
  • Jones KA; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
  • Kathayat RS; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
  • Azizi SA; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
  • Mathur R; Loyola University Chicago, Chicago, IL, USA.
  • Pearce CM; Loyola University Chicago, Chicago, IL, USA.
  • Ilc DJ; Loyola University Chicago, Chicago, IL, USA.
  • Husein H; Loyola University Chicago, Chicago, IL, USA.
  • Herbert AS; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
  • Bharti A; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, CA, 92093, USA.
  • Rathi B; Laboratory for Translational Chemistry and Drug Discovery, Hansraj College, University of Delhi, India.
  • Durvasula R; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA.
  • Becker DP; Loyola University Chicago, Chicago, IL, USA.
  • Dickinson BC; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
  • Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA. Electronic address: john.m.dye1.civ@mail.mil.
  • Kempaiah P; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA. Electronic address: kempaiah.prakasha@mayo.edu.
Methods ; 195: 57-71, 2021 11.
Article in En | MEDLINE | ID: mdl-33453392
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Drug Delivery Systems / Coronavirus 3C Proteases / SARS-CoV-2 / Indoles / Maleimides Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Methods Journal subject: BIOQUIMICA Year: 2021 Type: Article Affiliation country: United States
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Drug Delivery Systems / Coronavirus 3C Proteases / SARS-CoV-2 / Indoles / Maleimides Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Methods Journal subject: BIOQUIMICA Year: 2021 Type: Article Affiliation country: United States