Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery.

Munford, Robert S; Weiss, Jerrold P; Lu, Mingfang

Munford, Robert S; Weiss, Jerrold P; Lu, Mingfang.

Affiliation

Munford RS; Laboratory of Clinical Immunology and Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: munfordrs@niaid.nih.gov.
Weiss JP; Inflammation Program, University of Iowa, Iowa City, Iowa, USA.
Lu M; Department of Immunology and Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address: mingfanglu@fudan.edu.cn.

J Biol Chem ; 295(51): 17842-17851, 2020 12 18.

Article in En | MEDLINE | ID: mdl-33454018

Subject(s)

Carboxylic Ester Hydrolases/metabolism; Gram-Negative Bacteria/metabolism; Lipopolysaccharides/metabolism; Animals; Carboxylic Ester Hydrolases/chemistry; Carboxylic Ester Hydrolases/genetics; Humans; Lung/immunology; Lung/metabolism; Lymphocyte Antigen 96/chemistry; Lymphocyte Antigen 96/metabolism; Neutrophils/metabolism; Toll-Like Receptor 4/chemistry; Toll-Like Receptor 4/metabolism

Key words

AOAH; CD14; Toll-like receptor 4 (TLR4); acyloxyacyl hydrolase; colitis; inflammation; lipid A; lipopolysaccharide (LPS); macrophage; natural killer cells (NK cells); tolerance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carboxylic Ester Hydrolases / Lipopolysaccharides / Gram-Negative Bacteria Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2020 Type: Article

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