Autoinhibitory elements of the Chd1 remodeler block initiation of twist defects by destabilizing the ATPase motor on the nucleosome.

Nodelman, Ilana M; Shen, Zhongtian; Levendosky, Robert F; Bowman, Gregory D

Nodelman, Ilana M; Shen, Zhongtian; Levendosky, Robert F; Bowman, Gregory D.

Affiliation

Nodelman IM; Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218.
Shen Z; Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218.
Levendosky RF; Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218.
Bowman GD; Thomas C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218 gdbowman@jhu.edu.

Proc Natl Acad Sci U S A ; 118(4)2021 01 26.

Article in En | MEDLINE | ID: mdl-33468676

Subject(s)

Adenosine Triphosphatases/genetics; DNA-Binding Proteins/genetics; Nucleosomes/genetics; Saccharomyces cerevisiae Proteins/genetics; Adenosine Triphosphatases/chemistry; Adenosine Triphosphate/genetics; Chromatin Assembly and Disassembly/genetics; Chromosomes/genetics; DNA-Binding Proteins/chemistry; Histones/chemistry; Histones/genetics; Hydrolysis; Nucleosomes/chemistry; Protein Binding/genetics; Protein Domains/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins/chemistry

Key words

Snf2 ATPase; allostery; asymmetric histone core; chromatin remodeling; nucleosome sliding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nucleosomes / Adenosine Triphosphatases / Saccharomyces cerevisiae Proteins / DNA-Binding Proteins Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article

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