Elucidating the cellular dynamics of the brain with single-cell RNA sequencing.

Cardona-Alberich, Aida; Tourbez, Manon; Pearce, Sarah F; Sibley, Christopher R

Cardona-Alberich, Aida; Tourbez, Manon; Pearce, Sarah F; Sibley, Christopher R.

Affiliation

Cardona-Alberich A; Institute of Quantitative Biology, Biochemistry and Biotechnology, School of Biological Sciences, Edinburgh University, Edinburgh, UK.
Tourbez M; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK.
Pearce SF; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK.
Sibley CR; Institute of Quantitative Biology, Biochemistry and Biotechnology, School of Biological Sciences, Edinburgh University, Edinburgh, UK.

RNA Biol ; 18(7): 1063-1084, 2021 07.

Article in En | MEDLINE | ID: mdl-33499699

Subject(s)

Brain/metabolism; Nerve Tissue Proteins/genetics; Neurodegenerative Diseases/genetics; Neurodevelopmental Disorders/genetics; Neurons/metabolism; RNA, Messenger/genetics; Single-Cell Analysis/methods; Animals; Brain/pathology; Computational Biology/methods; DNA Barcoding, Taxonomic; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Humans; Nerve Tissue Proteins/metabolism; Neurodegenerative Diseases/metabolism; Neurodegenerative Diseases/pathology; Neurodevelopmental Disorders/metabolism; Neurodevelopmental Disorders/pathology; Neurons/pathology; RNA, Messenger/metabolism; Sequence Analysis, RNA/methods; Transcriptome

Key words

Single-cell; neurodegeneration; neurodevelopmental disorder; scRNA-seq; single-nuclei; snRNA-seq

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / RNA, Messenger / Neurodegenerative Diseases / Single-Cell Analysis / Neurodevelopmental Disorders / Nerve Tissue Proteins / Neurons Limits: Animals / Humans Language: En Journal: RNA Biol Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article Affiliation country: United kingdom

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