Wound infection following implant removal of foot, ankle, lower leg or patella; a protocol for a multicenter randomized controlled trial investigating the (cost-)effectiveness of 2 g of prophylactic cefazolin compared to placebo (WIFI-2 trial).

Sanders, Fay R K; Penning, Diederick; Backes, Manouk; Dingemans, Siem A; van Dieren, Susan; Eskes, Anne M; Goslings, J Carel; Kloen, Peter; Mathôt, Ron A A; Schep, Niels W L; Spijkerman, Ingrid J B; Schepers, Tim

Wound infection following implant removal of foot, ankle, lower leg or patella; a protocol for a multicenter randomized controlled trial investigating the (cost-)effectiveness of 2 g of prophylactic cefazolin compared to placebo (WIFI-2 trial).

Sanders, Fay R K; Penning, Diederick; Backes, Manouk; Dingemans, Siem A; van Dieren, Susan; Eskes, Anne M; Goslings, J Carel; Kloen, Peter; Mathôt, Ron A A; Schep, Niels W L; Spijkerman, Ingrid J B; Schepers, Tim.

Affiliation

Sanders FRK; Trauma Surgery, Amsterdam UMC, Loc. AMC, G4-137, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Penning D; Trauma Surgery, Amsterdam UMC, Loc. AMC, G4-137, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Backes M; Trauma Surgery, Amsterdam UMC, Loc. AMC, G4-137, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Dingemans SA; Trauma Surgery, Amsterdam UMC, Loc. AMC, G4-137, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
van Dieren S; Trauma Surgery, Amsterdam UMC, Loc. AMC, G4-137, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Eskes AM; Trauma Surgery, Amsterdam UMC, Loc. AMC, G4-137, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Goslings JC; Trauma Surgery, OLVG, Loc. West, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands.
Kloen P; Orthopedic Surgery, Amsterdam UMC, Loc. AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Mathôt RAA; Hospital Pharmacy, Amsterdam UMC, Loc. AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Schep NWL; Trauma Surgery, Maasstad Ziekenhuis, Maasstadweg 21, 3079 DZ, Rotterdam, The Netherlands.
Spijkerman IJB; Medical Microbiology, Amsterdam UMC, Loc. AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Schepers T; Trauma Surgery, Amsterdam UMC, Loc. AMC, G4-137, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. t.schepers@amsterdamumc.nl.

BMC Surg ; 21(1): 69, 2021 Feb 01.

Article in En | MEDLINE | ID: mdl-33522909

Subject(s)

Anti-Bacterial Agents; Bones of Lower Extremity/surgery; Cefazolin; Device Removal/adverse effects; Fractures, Bone/surgery; Surgical Wound Infection; Adult; Ankle; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/economics; Anti-Bacterial Agents/therapeutic use; Antibiotic Prophylaxis/economics; Antibiotic Prophylaxis/methods; Bones of Lower Extremity/injuries; Cefazolin/administration & dosage; Cefazolin/economics; Cefazolin/therapeutic use; Cost-Benefit Analysis; Device Removal/economics; Double-Blind Method; Elective Surgical Procedures/adverse effects; Elective Surgical Procedures/economics; Fracture Fixation, Internal/instrumentation; Humans; Infusions, Intravenous; Leg; Lower Extremity; Patella; Surgical Wound Infection/drug therapy; Surgical Wound Infection/economics; Surgical Wound Infection/etiology; Surgical Wound Infection/prevention & control

Key words

Ankle; Antibiotic prophylaxis; Cefazolin; Foot; Implant removal; Lower extremity; Orthopedic surgery; Surgical site infections; Trauma surgery

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Surgical Wound Infection / Cefazolin / Device Removal / Bones of Lower Extremity / Fractures, Bone / Anti-Bacterial Agents Type of study: Clinical_trials / Etiology_studies / Guideline / Health_economic_evaluation / Qualitative_research Limits: Adult / Humans Language: En Journal: BMC Surg Year: 2021 Type: Article Affiliation country: Netherlands

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