Treatment implications of a delayed diagnosis of maturity-onset diabetes of the young.
Intern Med J
; 51(1): 116-120, 2021 Jan.
Article
in En
| MEDLINE
| ID: mdl-33572031
ABSTRACT
Maturity-onset diabetes of the young (MODY) is a rare form of monogeneic diabetes that classically presents as non-insulin requiring diabetes with evidence of autosomal dominant inheritance in individuals who are typically young and lean. However, these criteria do not capture all cases and can also overlap with other types of diabetes. The hepatocyte nuclear factor-1 alpha (HNF1A) mutation is a common cause of MODY and is highly sensitive to sulphonylureas, which should be first-line therapy. Our case represents the diagnostic challenges of HNF1A MODY and the implications of a delayed diagnosis, which can lead to reduced success of sulphonylurea treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 2
/
Delayed Diagnosis
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Intern Med J
Journal subject:
MEDICINA INTERNA
Year:
2021
Type:
Article
Affiliation country:
Australia