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Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents.
Shao, Hao; Foley, David W; Huang, Shiliang; Abbas, Abdullahi Y; Lam, Frankie; Gershkovich, Pavel; Bradshaw, Tracey D; Pepper, Chris; Fischer, Peter M; Wang, Shudong.
Affiliation
  • Shao H; School of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Foley DW; School of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Huang S; School of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Abbas AY; School of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Lam F; Drug Discovery and Development, Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5001, Australia.
  • Gershkovich P; School of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Bradshaw TD; School of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
  • Pepper C; Brighton and Sussex Medical School, University of Sussex, Brighton, East Sussex, BN1 9PX, UK.
  • Fischer PM; School of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. Electronic address: peter.fischer@nottingham.ac.uk.
  • Wang S; School of Pharmacy and Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK; Drug Discovery and Development, Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5001, Australia. Electronic address: shudong.wang@unisa.edu.au.
Eur J Med Chem ; 214: 113244, 2021 Mar 15.
Article in En | MEDLINE | ID: mdl-33581551
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Drug Design / Cyclin-Dependent Kinase 9 / Protein Kinase Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2021 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Drug Design / Cyclin-Dependent Kinase 9 / Protein Kinase Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2021 Type: Article Affiliation country: United kingdom