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Immune-related Gene Expression Predicts Response to Neoadjuvant Chemotherapy but not Additional Benefit from PD-L1 Inhibition in Women with Early Triple-negative Breast Cancer.
Sinn, Bruno V; Loibl, Sibylle; Hanusch, Claus A; Zahm, Dirk-Michael; Sinn, Hans-Peter; Untch, Michael; Weber, Karsten; Karn, Thomas; Becker, Clemens; Marmé, Frederik; Schmitt, Wolfgang D; Müller, Volkmar; Schem, Christian; Treue, Denise; Stickeler, Elmar; Klauschen, Frederik; Burchardi, Nicole; Furlanetto, Jenny; van Mackelenbergh, Marion; Fasching, Peter A; Schneeweiss, Andreas; Denkert, Carsten.
Affiliation
  • Sinn BV; Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institut of Health, Berlin, Germany.
  • Loibl S; Berlin Institute of Health (BIH), Berlin, Germany.
  • Hanusch CA; German Breast Group Forschungs GmbH, Neu-Isenburg, Germany.
  • Zahm DM; Department of Gynecology, Rotkreuzklinikum München, Munich, Germany.
  • Sinn HP; Department of Gynecology and Obstetrics, SRH Waldklinikum Gera GmbH, Gera, Germany.
  • Untch M; Department of Pathology, Universitätsklinikum Heidelberg, Heidelberg, Germany.
  • Weber K; Department of Gynecology, Helios Kliniken Berlin-Buch, Berlin, Germany.
  • Karn T; German Breast Group Forschungs GmbH, Neu-Isenburg, Germany.
  • Becker C; Department of Gynecology and Obstetrics, Goethe-University, Frankfurt, Germany.
  • Marmé F; Department of Pathology, Rotkreuzklinikum München, Munich, Germany.
  • Schmitt WD; Department of Gynecology, Universitätsklinikum Mannheim, Mannheim, Germany.
  • Müller V; Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institut of Health, Berlin, Germany.
  • Schem C; Department of Gynecology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
  • Treue D; Mammazentrum Hamburg, Hamburg, Germany.
  • Stickeler E; Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institut of Health, Berlin, Germany.
  • Klauschen F; Department of Gynecology, Uniklinik RWTH Aachen, Aachen, Germany.
  • Burchardi N; Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institut of Health, Berlin, Germany.
  • Furlanetto J; German Breast Group Forschungs GmbH, Neu-Isenburg, Germany.
  • van Mackelenbergh M; German Breast Group Forschungs GmbH, Neu-Isenburg, Germany.
  • Fasching PA; Department of Gynecology and Obstetrics, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.
  • Schneeweiss A; Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
  • Denkert C; Nationales Centrum für Tumorerkrankungen, Universitätsklinikum und Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany.
Clin Cancer Res ; 27(9): 2584-2591, 2021 05 01.
Article in En | MEDLINE | ID: mdl-33593886
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Gene Expression Regulation, Neoplastic / Triple Negative Breast Neoplasms / Immune Checkpoint Inhibitors / Immunity Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Gene Expression Regulation, Neoplastic / Triple Negative Breast Neoplasms / Immune Checkpoint Inhibitors / Immunity Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: Germany