Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche.

Yasuda, Tadahito; Ishimoto, Takatsugu; Baba, Hideo

Yasuda, Tadahito; Ishimoto, Takatsugu; Baba, Hideo.

Affiliation

Yasuda T; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Ishimoto T; Gastrointestinal Cancer Biology, International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan.
Baba H; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Regen Ther ; 17: 8-12, 2021 Jun.

Article in En | MEDLINE | ID: mdl-33598509

Key words

ALDH, aldehyde dehydrogenase; ATP, adenosine triphosphate; CD44v, CD44 variant isoform; CSCs; CSCs, cancer stem cells; EMT, epithelialmesenchymal transition; EVs, extracellular vesicles; FAO, fatty acid oxidation; FBP1, fructose-1,6-biphosphatase 1; GLUT1, glucose transporter 1; GP6, glucose-6-phosphate; Glycolysis; HCC, hepatocellular carcinoma; HIF1a, hypoxia inducible factor 1a; IMP2, insulin-like growth factor 2; IncRNAs, long noncoding RNAs; LSCs, leukemia stem cells; Mitochondrial OXPHOS; NRF2, nuclear factor erythroid 2related factor 2; OXPHOS, oxidative phosphorylation; PDK1, pyruvate dehydrogenase kinase 1; PPP, pentose phosphate pathway; ROS; ROS, reactive oxygen species; SOD2, superoxide dismutase 2; Stromal niche; TCA, tricarboxylic acid; TICs, tumor initiating stem-like cells; mTORC1, mammalian target of rapamycin complex 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Regen Ther Year: 2021 Type: Article Affiliation country: Japan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Regen Ther Year: 2021 Type: Article Affiliation country: Japan