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Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting.
Du, Zhenfang; Brown, Benjamin P; Kim, Soyeon; Ferguson, Donna; Pavlick, Dean C; Jayakumaran, Gowtham; Benayed, Ryma; Gallant, Jean-Nicolas; Zhang, Yun-Kai; Yan, Yingjun; Red-Brewer, Monica; Ali, Siraj M; Schrock, Alexa B; Zehir, Ahmet; Ladanyi, Marc; Smith, Adam W; Meiler, Jens; Lovly, Christine M.
Affiliation
  • Du Z; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Brown BP; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, USA.
  • Kim S; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
  • Ferguson D; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.
  • Pavlick DC; Department of Chemistry, University of Akron, Akron, OH, USA.
  • Jayakumaran G; Department of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Benayed R; Foundation Medicine, Inc., Cambridge, MA, USA.
  • Gallant JN; Department of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Zhang YK; Department of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Yan Y; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Red-Brewer M; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Ali SM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Schrock AB; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Zehir A; Foundation Medicine, Inc., Cambridge, MA, USA.
  • Ladanyi M; Foundation Medicine, Inc., Cambridge, MA, USA.
  • Smith AW; Department of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Meiler J; Department of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  • Lovly CM; Department of Chemistry, University of Akron, Akron, OH, USA.
Nat Commun ; 12(1): 1382, 2021 03 02.
Article in En | MEDLINE | ID: mdl-33654076
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogenes / Gene Duplication / Molecular Targeted Therapy / ErbB Receptors Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogenes / Gene Duplication / Molecular Targeted Therapy / ErbB Receptors Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: United States