Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors.

Kreppel, Florian; Hagedorn, Claudia

Kreppel, Florian; Hagedorn, Claudia.

Affiliation

Kreppel F; Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University (UW/H), Stockumer Str. 10, 58448 Witten, Germany.
Hagedorn C; Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University (UW/H), Stockumer Str. 10, 58448 Witten, Germany.

Int J Mol Sci ; 22(5)2021 Feb 28.

Article in En | MEDLINE | ID: mdl-33670859

Subject(s)

Adenoviridae/genetics; Adenoviridae/immunology; Capsid/immunology; Genetic Vectors/genetics; Genetic Vectors/immunology; Animals; COVID-19; COVID-19 Vaccines/immunology; Capsid Proteins/genetics; Humans; Immunity; Immunogenicity, Vaccine; SARS-CoV-2/genetics; SARS-CoV-2/immunology

Key words

HPMA; PEGylation; adenovirus; cloaking; immune response; shielding; stealthing; vector

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenoviridae / Capsid / Genetic Vectors Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Germany

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