Binding of Amyloid ß(1-42)-Calmodulin Complexes to Plasma Membrane Lipid Rafts in Cerebellar Granule Neurons Alters Resting Cytosolic Calcium Homeostasis.

Poejo, Joana; Salazar, Jairo; Mata, Ana M; Gutierrez-Merino, Carlos

Poejo, Joana; Salazar, Jairo; Mata, Ana M; Gutierrez-Merino, Carlos.

Affiliation

Poejo J; Instituto de Biomarcadores de Patologías Moleculares, Universidad de Extremadura, 06006 Badajoz, Spain.
Salazar J; Instituto de Biomarcadores de Patologías Moleculares, Universidad de Extremadura, 06006 Badajoz, Spain.
Mata AM; Departamento de Química, Universidad Nacional Autónoma de Nicaragua-León, León 21000, Nicaragua.
Gutierrez-Merino C; Instituto de Biomarcadores de Patologías Moleculares, Universidad de Extremadura, 06006 Badajoz, Spain.

Int J Mol Sci ; 22(4)2021 Feb 17.

Article in En | MEDLINE | ID: mdl-33671444

Subject(s)

Amyloid beta-Peptides/metabolism; Calcium/metabolism; Calmodulin/metabolism; Cerebellum/metabolism; Cytosol/metabolism; Homeostasis; Membrane Microdomains/metabolism; Neurons/metabolism; Peptide Fragments/metabolism; Animals; Calcium Channels, L-Type/metabolism; Cell Survival; Fluorescence Resonance Energy Transfer; Humans; Protein Binding; Rats, Wistar

Key words

L-type calcium channels; amyloid ß(142); calmodulin; cerebellar granule neurons; cytosolic calcium homeostasis; lipid rafts

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Calmodulin / Cerebellum / Calcium / Amyloid beta-Peptides / Membrane Microdomains / Cytosol / Homeostasis / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Spain

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