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S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.
Pirie, Elaine; Oh, Chang-Ki; Zhang, Xu; Han, Xuemei; Cieplak, Piotr; Scott, Henry R; Deal, Amanda K; Ghatak, Swagata; Martinez, Fernando J; Yeo, Gene W; Yates, John R; Nakamura, Tomohiro; Lipton, Stuart A.
Affiliation
  • Pirie E; Department of Cellular and Molecular Medicine and Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093.
  • Oh CK; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Zhang X; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037.
  • Han X; Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037.
  • Cieplak P; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Scott HR; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037.
  • Deal AK; Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037.
  • Ghatak S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Martinez FJ; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037.
  • Yeo GW; Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037.
  • Yates JR; Bioinformatics and Structural Biology Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
  • Nakamura T; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Lipton SA; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037.
Proc Natl Acad Sci U S A ; 118(11)2021 03 16.
Article in En | MEDLINE | ID: mdl-33692125
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: S-Nitrosothiols / DNA-Binding Proteins / Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: S-Nitrosothiols / DNA-Binding Proteins / Frontotemporal Dementia / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article