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Scaffold repurposing of fendiline: Identification of potent KRAS plasma membrane localization inhibitors.
Wang, Pingyuan; van der Hoeven, Dharini; Ye, Na; Chen, Haiying; Liu, Zhiqing; Ma, Xiaoping; Montufar-Solis, Dina; Rehl, Kristen M; Cho, Kwang-Jin; Thapa, Sabita; Chen, Wei; van der Hoeven, Ransome; Frost, Jeffrey A; Hancock, John F; Zhou, Jia.
Affiliation
  • Wang P; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • van der Hoeven D; Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.
  • Ye N; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Chen H; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Liu Z; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
  • Ma X; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
  • Montufar-Solis D; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
  • Rehl KM; Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH, 45435, USA.
  • Cho KJ; Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH, 45435, USA.
  • Thapa S; Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.
  • Chen W; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
  • van der Hoeven R; Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.
  • Frost JA; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
  • Hancock JF; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Electronic address: john.f.hancock@uth.tmc.edu.
  • Zhou J; Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA. Electronic address: jizhou@utmb.edu.
Eur J Med Chem ; 217: 113381, 2021 May 05.
Article in En | MEDLINE | ID: mdl-33756124
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fendiline / Cell Membrane / Proto-Oncogene Proteins p21(ras) / Enzyme Inhibitors / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Eur J Med Chem Year: 2021 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fendiline / Cell Membrane / Proto-Oncogene Proteins p21(ras) / Enzyme Inhibitors / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Animals / Female / Humans Language: En Journal: Eur J Med Chem Year: 2021 Type: Article Affiliation country: United States