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Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia.
Sun, Josh; Uchiyama, Satoshi; Olson, Joshua; Morodomi, Yosuke; Cornax, Ingrid; Ando, Nao; Kohno, Yohei; Kyaw, May M T; Aguilar, Bernice; Haste, Nina M; Kanaji, Sachiko; Kanaji, Taisuke; Rose, Warren E; Sakoulas, George; Marth, Jamey D; Nizet, Victor.
Affiliation
  • Sun J; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Uchiyama S; Department of Pediatrics, UC San Diego, La Jolla, CA 92093, USA.
  • Olson J; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA 92093, USA.
  • Morodomi Y; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Cornax I; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Ando N; Department of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.
  • Kohno Y; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Kyaw MMT; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Aguilar B; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Haste NM; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Kanaji S; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Kanaji T; Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.
  • Rose WE; Department of Pediatrics, UC San Diego, La Jolla, CA 92093, USA.
  • Sakoulas G; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA 92093, USA.
  • Marth JD; Department of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.
  • Nizet V; Department of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.
Sci Transl Med ; 13(586)2021 03 24.
Article in En | MEDLINE | ID: mdl-33762439
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Pharmaceutical Preparations / Bacteremia Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2021 Type: Article Affiliation country: United States
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Pharmaceutical Preparations / Bacteremia Limits: Animals / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2021 Type: Article Affiliation country: United States