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Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.
Traylor, Matthew; Persyn, Elodie; Tomppo, Liisa; Klasson, Sofia; Abedi, Vida; Bakker, Mark K; Torres, Nuria; Li, Linxin; Bell, Steven; Rutten-Jacobs, Loes; Tozer, Daniel J; Griessenauer, Christoph J; Zhang, Yanfei; Pedersen, Annie; Sharma, Pankaj; Jimenez-Conde, Jordi; Rundek, Tatjana; Grewal, Raji P; Lindgren, Arne; Meschia, James F; Salomaa, Veikko; Havulinna, Aki; Kourkoulis, Christina; Crawford, Katherine; Marini, Sandro; Mitchell, Braxton D; Kittner, Steven J; Rosand, Jonathan; Dichgans, Martin; Jern, Christina; Strbian, Daniel; Fernandez-Cadenas, Israel; Zand, Ramin; Ruigrok, Ynte; Rost, Natalia; Lemmens, Robin; Rothwell, Peter M; Anderson, Christopher D; Wardlaw, Joanna; Lewis, Cathryn M; Markus, Hugh S.
Affiliation
  • Traylor M; Clinical Pharmacology and The Barts Heart Centre and NIHR Barts Biomedical Research Centre, Barts Health NHS Trust, William Harvey Research Institute, Queen Mary University of London, London, UK.
  • Persyn E; Department of Medical and Molecular Genetics, King's College London, London, UK.
  • Tomppo L; Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
  • Klasson S; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
  • Abedi V; Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, PA, USA.
  • Bakker MK; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.
  • Torres N; Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.
  • Li L; Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
  • Bell S; Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Rutten-Jacobs L; Product Development Personalized Health Care, F Hoffmann-La Roche, Basel, Switzerland.
  • Tozer DJ; Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Griessenauer CJ; Neuroscience Institute, Geisinger Health System, Danville, PA, USA; Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria.
  • Zhang Y; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA.
  • Pedersen A; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
  • Sharma P; Institute of Cardiovascular Research, Royal Holloway University of London, London, UK.
  • Jimenez-Conde J; Neurovascular Research Group, Department of Neurology of Hospital del Mar-IMIM (Institut Hospital del Mar d'Investigacions Mediques), Universitat Autonoma de Barcelona/DCEXS-Universitat Pompeu Fabra, Barcelona, Spain.
  • Rundek T; Evelyn F McKnight Brain Institute, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Grewal RP; Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA.
  • Lindgren A; Department of Neurology, Skane University Hospital, Lund, Sweden; Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
  • Meschia JF; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
  • Salomaa V; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Havulinna A; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM HiLIFE), Helsinki, Finland.
  • Kourkoulis C; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA; Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Crawford K; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Marini S; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Mitchell BD; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
  • Kittner SJ; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
  • Rosand J; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Program in Medical & Population Genetics, Br
  • Dichgans M; Institute for Stroke and Dementia Research (ISD), LMU Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Jern C; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
  • Strbian D; Department of Neurology, Helsinki University Hospital, Helsinki, Finland; Clinical Neurosciences, University of Helsinki, Helsinki, Finland.
  • Fernandez-Cadenas I; Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain; Neurovascular Research Laboratory and Neurovascular Unit, Institut de Recerca, Hospital Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain.
  • Zand R; Neuroscience Institute, Geisinger Health System, Danville, PA, USA.
  • Ruigrok Y; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.
  • Rost N; J Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • Lemmens R; Experimental Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium; VIB Center for Brain & Disease Research, Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  • Rothwell PM; Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.
  • Anderson CD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Program in Medical & Population Genetics, Br
  • Wardlaw J; Centre for Clinical Brain Sciences, UK Dementia Research Institute and Row Fogo Centre for Research into the Ageing Brain, University of Edinburgh, Edinburgh, UK.
  • Lewis CM; Department of Medical and Molecular Genetics, King's College London, London, UK; Social, Genetic, and Developmental Psychiatry Centre, King's College London, London, UK.
  • Markus HS; Clinical Neurosciences, University of Cambridge, Cambridge, UK. Electronic address: hsm32@medschl.cam.ac.uk.
Lancet Neurol ; 20(5): 351-361, 2021 05.
Article in En | MEDLINE | ID: mdl-33773637
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Genome-Wide Association Study / Stroke, Lacunar Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Country/Region as subject: America do norte / Europa / Oceania Language: En Journal: Lancet Neurol Journal subject: NEUROLOGIA Year: 2021 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Genome-Wide Association Study / Stroke, Lacunar Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Country/Region as subject: America do norte / Europa / Oceania Language: En Journal: Lancet Neurol Journal subject: NEUROLOGIA Year: 2021 Type: Article Affiliation country: United kingdom