A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activity.

Nataraj, Sarah E; Blain, Stacy W

Nataraj, Sarah E; Blain, Stacy W.

Affiliation

Nataraj SE; Program in Molecular and Cellular Biology, School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York.
Blain SW; Program in Molecular and Cellular Biology, School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, New York.

Cell Cycle ; 20(8): 808-818, 2021 04.

Article in En | MEDLINE | ID: mdl-33794722

Subject(s)

Cell Cycle Checkpoints/physiology; Cyclin-Dependent Kinase 2/metabolism; Cyclin-Dependent Kinase 6/metabolism; Protein Kinase Inhibitors/pharmacology; Protein Multimerization/physiology; Transforming Growth Factor beta/toxicity; Cell Cycle Checkpoints/drug effects; Cells, Cultured; Cyclin-Dependent Kinase 2/antagonists & inhibitors; Cyclin-Dependent Kinase 6/antagonists & inhibitors; Cyclin-Dependent Kinases/antagonists & inhibitors; Cyclin-Dependent Kinases/metabolism; Cyclins/antagonists & inhibitors; Cyclins/metabolism; Humans; Protein Multimerization/drug effects

Key words

CDK4; CDK6; Rb; cyclin-cdk6 dimer; g0 phase; p27

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 2 / Cyclin-Dependent Kinase 6 / Protein Multimerization / Cell Cycle Checkpoints Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Cycle Year: 2021 Type: Article

Fulltext

XML

PubMed Links

Search on Google