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Bovine Viral Diarrhea Virus (BVDV): A Preliminary Study on Antiviral Properties of Some Aromatic and Medicinal Plants.
Madeddu, Silvia; Marongiu, Alessandra; Sanna, Giuseppina; Zannella, Carla; Falconieri, Danilo; Porcedda, Silvia; Manzin, Aldo; Piras, Alessandra.
Affiliation
  • Madeddu S; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
  • Marongiu A; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
  • Sanna G; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
  • Zannella C; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
  • Falconieri D; Department of Experimental Medicine, University of Study of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
  • Porcedda S; State Industrial Technical Institute "Michele Giua", 09100 Cagliari, Italy.
  • Manzin A; Department of Chemical and Geological Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
  • Piras A; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy.
Pathogens ; 10(4)2021 Mar 29.
Article in En | MEDLINE | ID: mdl-33805453
ABSTRACT
Plant products provide an alternative and successful source of lead compounds for the pharmaceutical industry. The present study was aimed to evaluate, in cell-based assays, the antiviral properties of essential oils obtained from plants that commonly grow in Sardinia, Italy, against a broad spectrum of RNA/DNA viruses. The essential oils of Helichrisumitalicum (Roth) G. Don ssp. microphyllum (Willd.) Nyman, Laurus nobilis L., Mirtuscommunis L., Pistacia lentiscus L., Salvia officinalis L., Saturejathymbra L., Lavandula angustifolia Mill., Foeniculum vulgare Mill., and Eucalyptus globulus Labill. were extracted by hydrodistillation and analyzed by gas chromatography mass spectrometry (GC-MS). Interestingly, the essential oil of Salvia officinalis showed moderate activity against bovine viral diarrhea virus (BVDV), an enveloped RNA virus belonging to the Flaviviridae family. BVDV is responsible for several clinical manifestations in bovines, including respiratory, gastroenteric, and reproductive diseases, with a significant economic impact. With the aim to individuate the constituent of the Salvia officinalis responsible for the biological activity, we tested the major components of the oil camphene, ß-pinene, limonene, 1,8-cineole, cis-thujone, camphor, (E)-caryophyllene, and α-humulene. Here, we describe α-humulene as an active component that is non-cytotoxic and active against BVDV (EC50 = 36 µM). Its antiviral effects were evaluated using virucidal cytopathic effect inhibition and viral yield reduction assays. This is the first scientific report showing the anti BVDV effects of Salvia officinalis essential oil and α-humulene as the main active component.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pathogens Year: 2021 Type: Article Affiliation country: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pathogens Year: 2021 Type: Article Affiliation country: Italy