Safety and Efficacy of Ustekinumab in the Inflammatory Bowel Disease of Chronic Granulomatous Disease.

Bhattacharya, Sumona; Marciano, Beatriz E; Malech, Harry L; Quezado, Martha; Holland, Steven M; De Ravin, Suk See; Zerbe, Christa S; Heller, Theo

Bhattacharya, Sumona; Marciano, Beatriz E; Malech, Harry L; Quezado, Martha; Holland, Steven M; De Ravin, Suk See; Zerbe, Christa S; Heller, Theo.

Affiliation

Bhattacharya S; Digestive Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: Sumona.bhattacharya@nih.gov.
Marciano BE; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Malech HL; Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Quezado M; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Holland SM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
De Ravin SS; Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Zerbe CS; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Heller T; Translational Hepatology Section, Liver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: theoh@intra.niddk.nih.gov.

Clin Gastroenterol Hepatol ; 20(2): 461-464.e2, 2022 02.

Article in En | MEDLINE | ID: mdl-33813069

ABSTRACT

ABSTRACT

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by mutations encoding the NADPH oxidase complex.1 Those affected are at increased risk of bacterial and fungal infections and require antimicrobial prophylaxis. Dysregulated inflammation may cause inflammatory bowel disease (IBD), termed CGD-associated IBD or CGD colitis, a distinct entity from Crohn's disease (CD) or ulcerative colitis (UC).

Subject(s)

Colitis, Ulcerative; Colitis; Crohn Disease; Granulomatous Disease, Chronic; Inflammatory Bowel Diseases; Colitis/complications; Colitis, Ulcerative/complications; Crohn Disease/complications; Granulomatous Disease, Chronic/complications; Granulomatous Disease, Chronic/drug therapy; Granulomatous Disease, Chronic/genetics; Humans; Inflammatory Bowel Diseases/complications; Inflammatory Bowel Diseases/drug therapy; Ustekinumab/adverse effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Colitis, Ulcerative / Crohn Disease / Colitis / Granulomatous Disease, Chronic Limits: Humans Language: En Journal: Clin Gastroenterol Hepatol Journal subject: GASTROENTEROLOGIA Year: 2022 Type: Article

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