Ivacaftor partially corrects airway inflammation in a humanized G551D rat.

Green, Morgan; Lindgren, Natalie; Henderson, Alexander; Keith, Johnathan D; Oden, Ashley M; Birket, Susan E

Green, Morgan; Lindgren, Natalie; Henderson, Alexander; Keith, Johnathan D; Oden, Ashley M; Birket, Susan E.

Affiliation

Green M; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Lindgren N; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Henderson A; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Keith JD; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Oden AM; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Birket SE; Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Am J Physiol Lung Cell Mol Physiol ; 320(6): L1093-L1100, 2021 06 01.

Article in En | MEDLINE | ID: mdl-33825507

Subject(s)

Aminophenols/pharmacology; Cystic Fibrosis/drug therapy; Inflammation/drug therapy; Ion Transport/drug effects; Quinolones/pharmacology; Animals; Cystic Fibrosis Transmembrane Conductance Regulator/drug effects; Lung/drug effects; Molecular Targeted Therapy/methods; Mucociliary Clearance/drug effects; Rats, Transgenic

Key words

G551D; cystic fibrosis; inflammation; ivacaftor; rat

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ion Transport / Quinolones / Cystic Fibrosis / Aminophenols / Inflammation Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2021 Type: Article

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