Eicosapentaenoic and docosahexaenoic acids attenuate methotrexate-induced apoptosis and suppression of splenic T, B-Lymphocytes and macrophages with modulation of expression of CD3, CD20 and CD68.

Elsayed, Hassan Reda Hassan; Anbar, Hanan S; Rabei, Mohammed R; Adel, Mohamed; El-Gamal, Randa

Elsayed, Hassan Reda Hassan; Anbar, Hanan S; Rabei, Mohammed R; Adel, Mohamed; El-Gamal, Randa.

Affiliation

Elsayed HRH; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, 35516, Egypt; Department of Anatomy, Faculty of Medicine, Horus University, New Damietta, Egypt. Electronic address: hasan_reda@yahoo.com.
Anbar HS; Department of Clinical Pharmacy and Pharmacotherapeutics, Dubai Pharmacy College for Girls, Dubai, 19099, United Arab Emirates.
Rabei MR; Department of Physiology, Faculty of Medicine, Mansoura University, 35516, Egypt.
Adel M; Department of Physiology, Faculty of Medicine, Mansoura University, 35516, Egypt.
El-Gamal R; Department of Medical Biochemistry, And Mansoura experimental research center, Faculty of Medicine, Mansoura University, 35516, Egypt.

Tissue Cell ; 72: 101533, 2021 Oct.

Article in En | MEDLINE | ID: mdl-33838352

Subject(s)

Antigens, CD/metabolism; Apoptosis; B-Lymphocytes/metabolism; Docosahexaenoic Acids/pharmacology; Eicosapentaenoic Acid/pharmacology; Macrophages/metabolism; Methotrexate/adverse effects; T-Lymphocytes/metabolism; Animals; Apoptosis/drug effects; B-Lymphocytes/drug effects; Caspase 3/metabolism; Glutathione/metabolism; Macrophages/drug effects; Male; Malondialdehyde/metabolism; Oxidative Stress/drug effects; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats, Sprague-Dawley; Spleen/drug effects; Spleen/immunology; Spleen/pathology; T-Lymphocytes/drug effects; Tumor Necrosis Factor-alpha/metabolism

Key words

Docosahexaenoic (DHA); Eicosapentaenoic (EPA); Lymphocytes; Macrophages; Methotrexate; Omega-3 fatty acids; Polyunsaturated fatty acids; Spleen

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / T-Lymphocytes / Antigens, CD / Eicosapentaenoic Acid / Docosahexaenoic Acids / Methotrexate / Apoptosis / Macrophages Limits: Animals Language: En Journal: Tissue Cell Year: 2021 Type: Article

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