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The antibiotic darobactin mimics a ß-strand to inhibit outer membrane insertase.
Kaur, Hundeep; Jakob, Roman P; Marzinek, Jan K; Green, Robert; Imai, Yu; Bolla, Jani Reddy; Agustoni, Elia; Robinson, Carol V; Bond, Peter J; Lewis, Kim; Maier, Timm; Hiller, Sebastian.
Affiliation
  • Kaur H; Biozentrum, University of Basel, Basel, Switzerland.
  • Jakob RP; Biozentrum, University of Basel, Basel, Switzerland.
  • Marzinek JK; Bioinformatics Institute (A*STAR), Singapore, Singapore.
  • Green R; Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
  • Imai Y; Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.
  • Bolla JR; Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, UK.
  • Agustoni E; The Kavli Institute for Nanoscience Discovery, Oxford, UK.
  • Robinson CV; Biozentrum, University of Basel, Basel, Switzerland.
  • Bond PJ; Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, UK.
  • Lewis K; The Kavli Institute for Nanoscience Discovery, Oxford, UK.
  • Maier T; Bioinformatics Institute (A*STAR), Singapore, Singapore.
  • Hiller S; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Nature ; 593(7857): 125-129, 2021 05.
Article in En | MEDLINE | ID: mdl-33854236
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylpropionates / Bacterial Outer Membrane Proteins / Escherichia coli Proteins / Escherichia coli / Anti-Bacterial Agents Language: En Journal: Nature Year: 2021 Type: Article Affiliation country: Switzerland
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylpropionates / Bacterial Outer Membrane Proteins / Escherichia coli Proteins / Escherichia coli / Anti-Bacterial Agents Language: En Journal: Nature Year: 2021 Type: Article Affiliation country: Switzerland