Electrochemical and Photocatalytic Oxidative Coupling of Ketones via Silyl Bis-enol Ethers.
J Org Chem
; 86(9): 6600-6611, 2021 May 07.
Article
in En
| MEDLINE
| ID: mdl-33881862
ABSTRACT
Diastereoselective oxidative coupling of ketones through a silyl bis-enol ether intermediate by anodic and photocatalytic oxidation is reported. These methods provide several 1,4-diketones in good yields without the need for stoichiometric metal oxidants. The strategic use of a silicon tether enables the coupling of both aromatic and aliphatic ketones as well as the synthesis of quaternary centers. Cyclic voltammetry is used to gain insight into the oxidation events of the reaction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2021
Type:
Article
Affiliation country:
United States