Mangiferin Inhibits Apoptosis in Doxorubicin-Induced Vascular Endothelial Cells via the Nrf2 Signaling Pathway.

Ismail, Mohammad Bani; Rajendran, Peramaiyan; AbuZahra, Hamad Mohammed; Veeraraghavan, Vishnu Priya

Ismail, Mohammad Bani; Rajendran, Peramaiyan; AbuZahra, Hamad Mohammed; Veeraraghavan, Vishnu Priya.

Affiliation

Ismail MB; Department of Biological Sciences, College of Science, King Faisal University, Al Ahsa 31982, Saudi Arabia.
Rajendran P; Department of Biological Sciences, College of Science, King Faisal University, Al Ahsa 31982, Saudi Arabia.
AbuZahra HM; Department of Biological Sciences, College of Science, King Faisal University, Al Ahsa 31982, Saudi Arabia.
Veeraraghavan VP; Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600 077, India.

Int J Mol Sci ; 22(8)2021 Apr 20.

Article in En | MEDLINE | ID: mdl-33923922

Subject(s)

Doxorubicin/pharmacology; Human Umbilical Vein Endothelial Cells/drug effects; Human Umbilical Vein Endothelial Cells/metabolism; NF-E2-Related Factor 2/metabolism; Xanthones/pharmacology; Antioxidants/metabolism; Apoptosis/drug effects; Blotting, Western; Cell Survival/drug effects; Cell Survival/genetics; DNA Fragmentation/drug effects; Fluorescent Antibody Technique; Humans; In Situ Nick-End Labeling; NF-E2-Related Factor 2/genetics; Oxidative Stress/drug effects; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects; Signal Transduction/genetics

Key words

Nrf2; apoptosis; doxorubicin; mangiferin; oxidative stress; reactive oxygen species

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Xanthones / NF-E2-Related Factor 2 / Human Umbilical Vein Endothelial Cells Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Saudi Arabia

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