Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy.

Lecoutey, Cédric; Legay, Rémi; Davis, Audrey; Sopková-de Oliveira Santos, Jana; Dallemagne, Patrick; Rochais, Christophe

Lecoutey, Cédric; Legay, Rémi; Davis, Audrey; Sopková-de Oliveira Santos, Jana; Dallemagne, Patrick; Rochais, Christophe.

Affiliation

Lecoutey C; Normandie Univ, Unicaen, Cermn, 14000 Caen, France.
Legay R; Normandie Univ, Unicaen, Cermn, 14000 Caen, France.
Davis A; Normandie Univ, Unicaen, Cermn, 14000 Caen, France.
Sopková-de Oliveira Santos J; Normandie Univ, Unicaen, Cermn, 14000 Caen, France.
Dallemagne P; Normandie Univ, Unicaen, Cermn, 14000 Caen, France.
Rochais C; Normandie Univ, Unicaen, Cermn, 14000 Caen, France.

Molecules ; 26(9)2021 Apr 26.

Article in En | MEDLINE | ID: mdl-33926141

Subject(s)

Cholinesterase Inhibitors/chemistry; Drug Development; Molecular Docking Simulation; Molecular Dynamics Simulation; Acetylcholinesterase/chemistry; Acetylcholinesterase/metabolism; Binding Sites; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors/chemical synthesis; Cholinesterase Inhibitors/pharmacology; Humans; Hydrogen Bonding; Ligands; Molecular Conformation; Protein Binding; Structure-Activity Relationship

Key words

5-HT6R; Alzheimer's disease; MTDL; acetylcholinesterase; donecopride

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cholinesterase Inhibitors / Molecular Dynamics Simulation / Molecular Docking Simulation / Drug Development Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: France

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