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Conventional Ultrasound Combined With Contrast-Enhanced Ultrasound in Differential Diagnosis of Gallbladder Cholesterol and Adenomatous Polyps (1-2 cm).
Wang, Xue; Zhu, Jia-An; Liu, Yue-Jie; Liu, Yi-Qun; Che, Dong-Dong; Niu, Si-Hua; Gao, Shuang; Chen, Ding-Bao.
Affiliation
  • Wang X; Department of Ultrasound, Peking University People's Hospital, Beijing, China.
  • Zhu JA; Department of Ultrasound, Peking University People's Hospital, Beijing, China.
  • Liu YJ; Department of Ultrasound, Peking University People's Hospital, Beijing, China.
  • Liu YQ; Department of Ultrasound, Peking University People's Hospital, Beijing, China.
  • Che DD; Department of Ultrasound, Peking University People's Hospital, Beijing, China.
  • Niu SH; Department of Ultrasound, Peking University People's Hospital, Beijing, China.
  • Gao S; Department of Ultrasound, Peking University People's Hospital, Beijing, China.
  • Chen DB; Department of Pathology, Peking University People's Hospital, Beijing, China.
J Ultrasound Med ; 41(3): 617-626, 2022 Mar.
Article in En | MEDLINE | ID: mdl-33938029
ABSTRACT

OBJECTIVES:

This study aimed to determine ultrasonic image characteristics that enable differentiation between cholesterol and adenomatous polyps and to assess the diagnostic efficacy of combining conventional ultrasound (CUS) with contrast-enhanced ultrasound (CEUS).

METHODS:

Eighty-nine patients with gallbladder polyps of 1-2 cm in diameter were enrolled and examined by CUS and CEUS before cholecystectomy. The appearances on CUS and CEUS were recorded and analyzed. The receiver operating characteristic (ROC) curve was used to calculate the optimal size threshold for distinguishing cholesterol from adenomatous polyps. A logistic regression analysis was performed to identify diagnostic variables. ROC analysis was performed to evaluate the diagnostic efficacy of the size, the independent variables, and the combined factors.

RESULTS:

There were differences in size, number, vascularity on CUS and intralesional vascular shape, wash-out, and area under the curve on CEUS between the two groups (P < .05). ROC analysis indicated that a maximum diameter of 1.45 cm was the optimal threshold for the prediction of adenomatous polyps. The logistic regression analysis proved that the single polyp, presence of vascularity, and intralesional linear vessels were associated with adenomatous polyps (P < .05). ROC analysis showed that the area under the ROC curve, sensitivity, and specificity for the combination of the three independent variables were 0.858, 87.3%, and 67.6%. The number combined with intralesional vascular shape had the highest diagnostic sensitivity of 91.2%.

CONCLUSIONS:

The combination of CUS and CEUS demonstrated great significance in the differential diagnosis of cholesterol and adenomatous polyps.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyps / Adenomatous Polyps / Gallbladder Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: J Ultrasound Med Year: 2022 Type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyps / Adenomatous Polyps / Gallbladder Neoplasms Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: J Ultrasound Med Year: 2022 Type: Article Affiliation country: China