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Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection.
Engdahl, Taylor B; Kuzmina, Natalia A; Ronk, Adam J; Mire, Chad E; Hyde, Matthew A; Kose, Nurgun; Josleyn, Matthew D; Sutton, Rachel E; Mehta, Apoorva; Wolters, Rachael M; Lloyd, Nicole M; Valdivieso, Francisca R; Ksiazek, Thomas G; Hooper, Jay W; Bukreyev, Alexander; Crowe, James E.
Affiliation
  • Engdahl TB; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Kuzmina NA; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
  • Ronk AJ; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
  • Mire CE; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA; Animal Resource Center, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Hyde MA; Animal Resource Center, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Kose N; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Josleyn MD; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Sutton RE; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Mehta A; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Wolters RM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Lloyd NM; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
  • Valdivieso FR; Programa Hantavirus, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7590943, Chile.
  • Ksiazek TG; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA.
  • Hooper JW; Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA; Galveston National Laboratory, Galveston, TX 77550, USA. Electronic address: alexander.bukreyev@utmb.edu.
  • Crowe JE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Cell Rep ; 35(5): 109086, 2021 05 04.
Article in En | MEDLINE | ID: mdl-33951434
ABSTRACT
New World hantaviruses (NWHs) are endemic in North and South America and cause hantavirus cardiopulmonary syndrome (HCPS), with a case fatality rate of up to 40%. Knowledge of the natural humoral immune response to NWH infection is limited. Here, we describe human monoclonal antibodies (mAbs) isolated from individuals previously infected with Sin Nombre virus (SNV) or Andes virus (ANDV). Most SNV-reactive antibodies show broad recognition and cross-neutralization of both New and Old World hantaviruses, while many ANDV-reactive antibodies show activity for ANDV only. mAbs ANDV-44 and SNV-53 compete for binding to a distinct site on the ANDV surface glycoprotein and show potently neutralizing activity to New and Old World hantaviruses. Four mAbs show therapeutic efficacy at clinically relevant doses in hamsters. These studies reveal a convergent and potently neutralizing human antibody response to NWHs and suggest therapeutic potential for human mAbs against HCPS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Orthohantavirus / Hantavirus Infections / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Orthohantavirus / Hantavirus Infections / Antibodies, Monoclonal Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2021 Type: Article Affiliation country: United States