Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints.

Cortés Martínez, Jordi; Geskus, Ronald B; Kim, KyungMann; Melis, Guadalupe Gómez

Cortés Martínez, Jordi; Geskus, Ronald B; Kim, KyungMann; Melis, Guadalupe Gómez.

Affiliation

Cortés Martínez J; Department of Statistics and Operations Research, Universitat Politècnica de Catalunya, Jordi Girona, 31, Barcelona, 08034, Spain. jordi.cortes-martinez@upc.edu.
Geskus RB; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Kim K; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford, United Kingdom.
Melis GG; Department of Biostatistics and Medical Informatics, University of Wisconsin, 600 Highland Ave, Madison, 53792, USA.

BMC Med Res Methodol ; 21(1): 99, 2021 05 06.

Article in En | MEDLINE | ID: mdl-33957892

Subject(s)

Research Design; Computer Simulation; Control Groups; Humans; Proportional Hazards Models; Sample Size

Key words

Composite endpoint; Copula; Non-Proportional Hazards; Progression-Free Survival; Randomized Controlled Trial; Simulation; Treatment Effect

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Research Design Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: BMC Med Res Methodol Journal subject: MEDICINA Year: 2021 Type: Article Affiliation country: Spain

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