Your browser doesn't support javascript.
loading
Treatment of donor-specific antibody-mediated rejection after heart transplantation by IgM-enriched human immunoglobulin.
Immohr, Moritz Benjamin; Akhyari, Payam; Aubin, Hug; Westenfeld, Ralf; Mehdiani, Arash; Bruno, Raphael Romano; Sipahi, Nihat Firat; Erbel-Khurtsidze, Sophiko; Reinecke, Petra; Tudorache, Igor; Lichtenberg, Artur; Boeken, Udo.
Affiliation
  • Immohr MB; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
  • Akhyari P; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
  • Aubin H; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
  • Westenfeld R; Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Medical School, Duesseldorf, Germany.
  • Mehdiani A; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
  • Bruno RR; Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Medical School, Duesseldorf, Germany.
  • Sipahi NF; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
  • Erbel-Khurtsidze S; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
  • Reinecke P; Institute of Pathology, Heinrich-Heine-University Medical School, Duesseldorf, Germany.
  • Tudorache I; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
  • Lichtenberg A; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
  • Boeken U; Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.
ESC Heart Fail ; 8(4): 3413-3417, 2021 08.
Article in En | MEDLINE | ID: mdl-33969938
Antibody-mediated graft rejection caused by donor-specific antibodies (DSA-MR) remains a serious problem after heart transplantation (HTx). IgM-enriched human intravenous immunoglobulin (IGM-IVIG) consists of 76% IgG, 12% IgM, and 12% IgA and provides a new multifactorial approach for DSA-MR. Between 2017 and 2020, four (P1-4) of 102 patients developed DSA-MR after HTx in our department and were repetitively treated with IGM-IVIG in combination with anti-thymocyte globulin. While in P1 and P4, DSA-MR occurred within the early post-operative interval, P2 and P3 developed DSA-MR approximately 1 year after transplantation. An impairment of ventricular function was observed in three of four patients. Furthermore, P1 and P4 suffered from malign ventricular arrhythmias. After the application of IGM-IVIG, the ventricular function recovered, and all patients could be discharged from the hospital. As part of a multifactorial therapeutic approach, treatment with IGM-IVIG seems to be a safe and effective strategy to address DSA-MR.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Heart Transplantation / Graft Rejection Limits: Humans Language: En Journal: ESC Heart Fail Year: 2021 Type: Article Affiliation country: Germany
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Heart Transplantation / Graft Rejection Limits: Humans Language: En Journal: ESC Heart Fail Year: 2021 Type: Article Affiliation country: Germany