Binding of thermalized and active membrane curvature-inducing proteins.
Soft Matter
; 17(22): 5560-5573, 2021 Jun 09.
Article
in En
| MEDLINE
| ID: mdl-33978669
ABSTRACT
The phase behavior of a membrane induced by the binding of curvature-inducing proteins is studied by a combination of analytical and numerical approaches. In thermal equilibrium under the detailed balance between binding and unbinding, the membrane exhibits three phases an unbound uniform flat phase (U), a bound uniform flat phase (B), and a separated/corrugated phase (SC). In the SC phase, the bound proteins form hexagonally-ordered bowl-shaped domains. The transitions between the U and SC phases and between the B and SC phases are second order and first order, respectively. At a small spontaneous curvature of the protein or high surface tension, the transition between B and SC phases becomes continuous. Moreover, a first-order transition between the U and B phases is found at zero spontaneous curvature driven by the Casimir-like interactions between rigid proteins. Furthermore, nonequilibrium dynamics is investigated by the addition of active binding and unbinding at a constant rate. The active binding and unbinding processes alter the stability of the SC phase.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteins
Language:
En
Journal:
Soft Matter
Year:
2021
Type:
Article
Affiliation country:
France