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A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria.
Adoke, Yeka; Zoleko-Manego, Rella; Ouoba, Serge; Tiono, Alfred B; Kaguthi, Grace; Bonzela, Juvêncio Eduardo; Duong, Tran Thanh; Nahum, Alain; Bouyou-Akotet, Marielle; Ogutu, Bernhards; Ouedraogo, Alphonse; Macintyre, Fiona; Jessel, Andreas; Laurijssens, Bart; Cherkaoui-Rbati, Mohammed H; Cantalloube, Cathy; Marrast, Anne Claire; Bejuit, Raphaël; White, David; Wells, Timothy N C; Wartha, Florian; Leroy, Didier; Kibuuka, Afizi; Mombo-Ngoma, Ghyslain; Ouattara, Daouda; Mugenya, Irène; Phuc, Bui Quang; Bohissou, Francis; Mawili-Mboumba, Denise P; Olewe, Fredrick; Soulama, Issiaka; Tinto, Halidou.
Affiliation
  • Adoke Y; Infectious Diseases Research Collaboration (IDRC), Nakasero Hill Road, P.O. Box 7475, Kampala, Uganda. yadoke@yahoo.com.
  • Zoleko-Manego R; Centre de Recherches Médicales de Lambaréné (CERMEL), BP 142, Lambaréné, Gabon.
  • Ouoba S; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep. of Medicine, University Medical Centre Hamburg-Eppendorf, Bernhard Nocht Straße 74, 20359, Hamburg, Germany.
  • Tiono AB; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de La Santé, Nanoro, Burkina Faso.
  • Kaguthi G; Unité de Recherche Clinique de Banfora, C/H Régional de Banfora, Centre National de Recherche Et de Formation Sur Le Paludisme (CNRFP), Ouagadougou, Province de la Comoé, Burkina Faso.
  • Bonzela JE; Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), P.O. Box 47855-00100, Nairobi, Kenya.
  • Duong TT; Chokwe Health Research and Training Centre, 1 Bairro, Zona Do Orli, CP 30, Chokwe, Mozambique.
  • Nahum A; National Institute of Malariology, Parasitology and Entomology, Hanoi, Vietnam.
  • Bouyou-Akotet M; Centre de Recherche Entomologique de Cotonou (CREC) and Hôpital La Croix de Zinvié, 06 BP 2604, Cotonou, Benin.
  • Ogutu B; Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine Et Des Sciences de La Santé, Université Des Sciences de La Santé, BP 4009, Libreville, Gabon.
  • Ouedraogo A; Kenya Medical Research Institute, Kisumu, Kenya.
  • Macintyre F; Unité de Recherche Clinique de Niangoloko, S/C Centre Medical de Niangoloko, Centre National de Recherche Et de Formation Sur Le Paludisme (CNRFP), BP 37, Niangoloko, Burkina Faso.
  • Jessel A; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, Post Box 1826, 1215, Geneva 15, Switzerland.
  • Laurijssens B; Sanofi Research and Development, 55 Corporate Drive, Bridgewater, NJ, 08807, USA.
  • Cherkaoui-Rbati MH; BEL Pharm Consulting, 116 Chemin du Moulin d'Ozil, 07140, Chambonas, France.
  • Cantalloube C; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, Post Box 1826, 1215, Geneva 15, Switzerland.
  • Marrast AC; Sanofi Research and Development, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Bejuit R; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, Post Box 1826, 1215, Geneva 15, Switzerland.
  • White D; Sanofi Research and Development, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Wells TNC; IQVIA CEVA, 4820 Emperor Boulevard, Durham, NC, 27703, USA.
  • Wartha F; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, Post Box 1826, 1215, Geneva 15, Switzerland.
  • Leroy D; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, Post Box 1826, 1215, Geneva 15, Switzerland.
  • Kibuuka A; Medicines for Malaria Venture (MMV), Route de Pré-Bois 20, Post Box 1826, 1215, Geneva 15, Switzerland.
  • Mombo-Ngoma G; Infectious Diseases Research Collaboration (IDRC), Nakasero Hill Road, P.O. Box 7475, Kampala, Uganda.
  • Ouattara D; Centre de Recherches Médicales de Lambaréné (CERMEL), BP 142, Lambaréné, Gabon.
  • Mugenya I; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Dep. of Medicine, University Medical Centre Hamburg-Eppendorf, Bernhard Nocht Straße 74, 20359, Hamburg, Germany.
  • Phuc BQ; Institute for Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany.
  • Bohissou F; Unité de Recherche Clinique de Banfora, C/H Régional de Banfora, Centre National de Recherche Et de Formation Sur Le Paludisme (CNRFP), Ouagadougou, Province de la Comoé, Burkina Faso.
  • Mawili-Mboumba DP; Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), P.O. Box 47855-00100, Nairobi, Kenya.
  • Olewe F; National Institute of Malariology, Parasitology and Entomology, Hanoi, Vietnam.
  • Soulama I; Centre de Recherche Entomologique de Cotonou (CREC) and Hôpital La Croix de Zinvié, 06 BP 2604, Cotonou, Benin.
  • Tinto H; Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine Et Des Sciences de La Santé, Université Des Sciences de La Santé, BP 4009, Libreville, Gabon.
Malar J ; 20(1): 222, 2021 May 19.
Article in En | MEDLINE | ID: mdl-34011358
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peroxides / Plasmodium falciparum / Adamantane / Ferrous Compounds / Malaria, Falciparum / Metallocenes / Aminoquinolines / Antimalarials Type of study: Clinical_trials / Guideline / Risk_factors_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Africa / Asia Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2021 Type: Article Affiliation country: Uganda
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peroxides / Plasmodium falciparum / Adamantane / Ferrous Compounds / Malaria, Falciparum / Metallocenes / Aminoquinolines / Antimalarials Type of study: Clinical_trials / Guideline / Risk_factors_studies Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Africa / Asia Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2021 Type: Article Affiliation country: Uganda