Club cell-specific role of programmed cell death 5 in pulmonary fibrosis.

Park, Soo-Yeon; Hong, Jung Yeon; Lee, Soo Yeon; Lee, Seung-Hyun; Kim, Mi Jeong; Kim, Soo Yeon; Kim, Kyung Won; Shim, Hyo Sup; Park, Moo Suk; Lee, Chun Geun; Elias, Jack A; Sohn, Myung Hyun; Yoon, Ho-Geun

Park, Soo-Yeon; Hong, Jung Yeon; Lee, Soo Yeon; Lee, Seung-Hyun; Kim, Mi Jeong; Kim, Soo Yeon; Kim, Kyung Won; Shim, Hyo Sup; Park, Moo Suk; Lee, Chun Geun; Elias, Jack A; Sohn, Myung Hyun; Yoon, Ho-Geun.

Affiliation

Park SY; Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Hong JY; Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Lee SY; Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Lee SH; Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kim MJ; Department of Biochemistry and Molecular Biology, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kim SY; Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kim KW; Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Shim HS; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Park MS; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Lee CG; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Elias JA; Department of Internal Medicine, Hanyang University, Seoul, Korea.
Sohn MH; Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Yoon HG; Department of Pediatrics and Institute of Allergy, Severance Medical Research Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea. mhsohn@yuhs.ac.

Nat Commun ; 12(1): 2923, 2021 05 19.

Article in En | MEDLINE | ID: mdl-34011956

Subject(s)

Apoptosis Regulatory Proteins/genetics; Idiopathic Pulmonary Fibrosis/genetics; Idiopathic Pulmonary Fibrosis/pathology; Neoplasm Proteins/genetics; Aged; Animals; Apoptosis Regulatory Proteins/deficiency; Apoptosis Regulatory Proteins/metabolism; Bronchioles/metabolism; Bronchioles/pathology; Cell Line; Disease Models, Animal; Epithelial Cells/metabolism; Epithelial Cells/pathology; Female; Gene Expression; Gene Knockdown Techniques; Humans; Lung/metabolism; Lung/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Middle Aged; Neoplasm Proteins/deficiency; Neoplasm Proteins/metabolism; Respiratory Mucosa/metabolism; Respiratory Mucosa/pathology; Signal Transduction; Smad3 Protein/metabolism; Transforming Growth Factor beta/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis Regulatory Proteins / Idiopathic Pulmonary Fibrosis / Neoplasm Proteins Type of study: Prognostic_studies Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article

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