Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model.

Shi, Yewen; Xie, Tong-Xin; Leach, David G; Wang, Bingbing; Young, Simon; Osman, Abdullah A; Sikora, Andrew G; Ren, Xiaoyong; Hartgerink, Jeffrey D; Myers, Jeffrey N; Rangel, Roberto

Shi, Yewen; Xie, Tong-Xin; Leach, David G; Wang, Bingbing; Young, Simon; Osman, Abdullah A; Sikora, Andrew G; Ren, Xiaoyong; Hartgerink, Jeffrey D; Myers, Jeffrey N; Rangel, Roberto.

Affiliation

Shi Y; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.
Xie TX; Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Leach DG; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.
Wang B; Department of Chemistry, Department of Bioengineering, Rice University, Houston, Texas.
Young S; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.
Osman AA; Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at Houston, Houston, Texas.
Sikora AG; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.
Ren X; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.
Hartgerink JD; Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Myers JN; Department of Chemistry, Department of Bioengineering, Rice University, Houston, Texas.
Rangel R; Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.

Cancer Prev Res (Phila) ; 14(8): 767-778, 2021 08.

Article in En | MEDLINE | ID: mdl-34021022

Subject(s)

Immune Checkpoint Inhibitors/administration & dosage; Mouth Neoplasms/prevention & control; Precancerous Conditions/drug therapy; Programmed Cell Death 1 Receptor/immunology; 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal/administration & dosage; Carcinogenesis/chemically induced; Carcinogenesis/drug effects; Disease Models, Animal; Drug Delivery Systems; Female; Genes, p53/genetics; Head and Neck Neoplasms/chemically induced; Head and Neck Neoplasms/genetics; Head and Neck Neoplasms/pathology; Head and Neck Neoplasms/prevention & control; Humans; Injections, Intralesional; Male; Mice; Mice, Transgenic; Mouth Neoplasms/pathology; Precancerous Conditions/chemically induced; Precancerous Conditions/genetics; Precancerous Conditions/pathology; Programmed Cell Death 1 Receptor/antagonists & inhibitors; Quinolones; Squamous Cell Carcinoma of Head and Neck/chemically induced; Squamous Cell Carcinoma of Head and Neck/genetics; Squamous Cell Carcinoma of Head and Neck/pathology; Squamous Cell Carcinoma of Head and Neck/prevention & control

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precancerous Conditions / Mouth Neoplasms / Programmed Cell Death 1 Receptor / Immune Checkpoint Inhibitors Limits: Animals / Female / Humans / Male Language: En Journal: Cancer Prev Res (Phila) Journal subject: NEOPLASIAS Year: 2021 Type: Article

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