Increased excitation-inhibition balance and loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction.

Jami, Shekib A; Cameron, Scott; Wong, Jonathan M; Daly, Emily R; McAllister, A Kimberley; Gray, John A

Jami, Shekib A; Cameron, Scott; Wong, Jonathan M; Daly, Emily R; McAllister, A Kimberley; Gray, John A.

Affiliation

Jami SA; Center for Neuroscience, University of California, Davis, California.
Cameron S; Center for Neuroscience, University of California, Davis, California.
Wong JM; Center for Neuroscience, University of California, Davis, California.
Daly ER; Center for Neuroscience, University of California, Davis, California.
McAllister AK; Center for Neuroscience, University of California, Davis, California.
Gray JA; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California.

J Neurophysiol ; 126(1): 11-27, 2021 07 01.

Article in En | MEDLINE | ID: mdl-34038186

Subject(s)

Excitatory Postsynaptic Potentials/physiology; GABAergic Neurons/metabolism; Inhibitory Postsynaptic Potentials/physiology; Racemases and Epimerases/deficiency; Receptors, N-Methyl-D-Aspartate/deficiency; Synapses/metabolism; Animals; Female; Hippocampus/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Racemases and Epimerases/genetics; Receptors, N-Methyl-D-Aspartate/genetics; Schizophrenia/genetics; Schizophrenia/metabolism; Synapses/genetics

Key words

E/I balance; GABA; NMDA receptor; SRR; inhibition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Receptors, N-Methyl-D-Aspartate / Racemases and Epimerases / Excitatory Postsynaptic Potentials / Inhibitory Postsynaptic Potentials / GABAergic Neurons Limits: Animals Language: En Journal: J Neurophysiol Year: 2021 Type: Article

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