Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients.

Oliveres, Helena; Pesántez, David; Maurel, Joan

Oliveres, Helena; Pesántez, David; Maurel, Joan.

Affiliation

Oliveres H; Translational Genomics and Targeted Therapeutics in Solid Tumors Group, Medical Oncology Department, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.
Pesántez D; Translational Genomics and Targeted Therapeutics in Solid Tumors Group, Medical Oncology Department, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.
Maurel J; Translational Genomics and Targeted Therapeutics in Solid Tumors Group, Medical Oncology Department, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, 08036 Barcelona, Spain.

Int J Mol Sci ; 22(9)2021 May 09.

Article in En | MEDLINE | ID: mdl-34065119

Subject(s)

Colorectal Neoplasms/pathology; Colorectal Neoplasms/therapy; Biomarkers, Tumor; Colorectal Neoplasms/etiology; Colorectal Neoplasms/metabolism; Drug Resistance, Neoplasm/drug effects; Epithelial-Mesenchymal Transition/drug effects; Humans; Liquid Biopsy; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Staging; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Protein Processing, Post-Translational; Receptor, IGF Type 1/metabolism; Signal Transduction/drug effects; Treatment Outcome; Tumor Microenvironment/drug effects; ras Proteins/metabolism

Key words

insulin-like growth factor receptor; metastatic colorectal cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms Type of study: Etiology_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: Spain

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