Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA.

Suzuki, Hiroaki; Matsuoka, Masaaki

Suzuki, Hiroaki; Matsuoka, Masaaki.

Affiliation

Suzuki H; Department of Pharmacology, School of Medicine, Tokyo Medical University, Tokyo, Japan.
Matsuoka M; Department of Pharmacology, School of Medicine, Tokyo Medical University, Tokyo, Japan.

J Neurochem ; 158(3): 753-765, 2021 08.

Article in En | MEDLINE | ID: mdl-34081786

Subject(s)

Adenosine Deaminase/genetics; Arginine/genetics; C9orf72 Protein/genetics; Proline/genetics; RNA-Binding Proteins/genetics; Adenosine Deaminase/metabolism; Animals; Arginine/metabolism; C9orf72 Protein/metabolism; Dipeptides/genetics; Dipeptides/metabolism; HeLa Cells; Humans; Mice; Neurons/metabolism; Proline/metabolism; RNA-Binding Proteins/metabolism

Key words

ADAR; C9orf72; RNA editing; amyotrophic lateral sclerosis; frontotemporal dementia; neurodegeneration

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Proline / Adenosine Deaminase / RNA-Binding Proteins / C9orf72 Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neurochem Year: 2021 Type: Article Affiliation country: Japan

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