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ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition.
Anderson, Mark G; Zhang, Qian; Rodriguez, Luis E; Hecquet, Claudie M; Donawho, Cherrie K; Ansell, Peter J; Reilly, Edward B.
Affiliation
  • Anderson MG; AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL, 60064-6099, USA. mark.g.anderson@abbvie.com.
  • Zhang Q; AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL, 60064-6099, USA.
  • Rodriguez LE; AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL, 60064-6099, USA.
  • Hecquet CM; AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL, 60064-6099, USA.
  • Donawho CK; Formerly AbbVie, Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL, 60064, USA.
  • Ansell PJ; AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL, 60064-6099, USA.
  • Reilly EB; AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL, 60064-6099, USA.
BMC Cancer ; 21(1): 681, 2021 Jun 09.
Article in En | MEDLINE | ID: mdl-34107902
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Prolactin / Immunoconjugates / Cytotoxins / Poly(ADP-ribose) Polymerase Inhibitors Limits: Animals / Female / Humans Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Prolactin / Immunoconjugates / Cytotoxins / Poly(ADP-ribose) Polymerase Inhibitors Limits: Animals / Female / Humans Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: United States