TRough versus AUC Monitoring of cyclosporine: A randomized comparison of adverse drug reactions in adult allogeneic stem cell recipients (TRAM study).

Kuijvenhoven, Marianne A; Wilhelm, Abraham J; Meijer, Ellen; Janssen, Jeroen J W M; Swart, Eleonora L

Kuijvenhoven, Marianne A; Wilhelm, Abraham J; Meijer, Ellen; Janssen, Jeroen J W M; Swart, Eleonora L.

Affiliation

Kuijvenhoven MA; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Wilhelm AJ; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Meijer E; Department of Hematology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Janssen JJWM; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Swart EL; Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Eur J Haematol ; 107(3): 364-369, 2021 Sep.

Article in En | MEDLINE | ID: mdl-34114691

Subject(s)

Cyclosporine/adverse effects; Immunosuppressive Agents/adverse effects; Leukemia, Myeloid, Acute/therapy; Lymphoma/therapy; Multiple Myeloma/therapy; Nausea/chemically induced; Renal Tubular Transport, Inborn Errors/chemically induced; Adult; Area Under Curve; Cyclosporine/pharmacokinetics; Drug Monitoring/methods; Female; Graft Rejection/etiology; Graft Rejection/immunology; Graft Rejection/pathology; Graft Survival/physiology; Hematopoietic Stem Cell Transplantation/methods; Humans; Immunosuppressive Agents/pharmacokinetics; Leukemia, Myeloid, Acute/immunology; Leukemia, Myeloid, Acute/pathology; Lymphoma/immunology; Lymphoma/pathology; Male; Middle Aged; Multiple Myeloma/immunology; Multiple Myeloma/pathology; Nausea/immunology; Nausea/pathology; ROC Curve; Random Allocation; Renal Tubular Transport, Inborn Errors/immunology; Renal Tubular Transport, Inborn Errors/pathology; Transplantation, Homologous

Key words

cyclosporine; drug monitoring; drug-related side effects and adverse reaction; hematopoietic stem cell transplantation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Tubular Transport, Inborn Errors / Leukemia, Myeloid, Acute / Cyclosporine / Immunosuppressive Agents / Lymphoma / Multiple Myeloma / Nausea Type of study: Clinical_trials / Etiology_studies / Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Eur J Haematol Journal subject: HEMATOLOGIA Year: 2021 Type: Article Affiliation country: Netherlands

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