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Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients.
Chen, Yang; Li, Yanyan; Qi, Changsong; Zhang, Cheng; Liu, Dan; Deng, Youping; Fu, Yuanyuan; Khadka, Vedbar S; Wang, Daisy Dandan; Tan, Shanyang; Liu, Shujun; Peng, Zhi; Gong, Jifang; Lin, Peter Ping; Zhang, Xiaotian; Li, Jian; Li, Yilin; Shen, Lin.
Affiliation
  • Chen Y; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Li Y; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Qi C; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Zhang C; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Liu D; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Deng Y; Bioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Fu Y; Bioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Khadka VS; Bioinformatics Core, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Wang DD; Cytelligen, San Diego, CA, USA.
  • Tan S; Jiangsu Cowin Biotech Co., Ltd, China Medical City, Taizhou, Jiangsu, China.
  • Liu S; Jiangsu Cowin Biotech Co., Ltd, China Medical City, Taizhou, Jiangsu, China.
  • Peng Z; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Gong J; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Lin PP; Cytelligen, San Diego, CA, USA.
  • Zhang X; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Li J; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
  • Li Y; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. Electronic address: liyilin@bjcancer.org.
  • Shen L; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China. Electronic address: shenlin@bjmu.edu.cn.
Cancer Lett ; 517: 78-87, 2021 10 01.
Article in En | MEDLINE | ID: mdl-34126192
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Chromatin / Proto-Oncogene Proteins p21(ras) / Drug Resistance, Neoplasm / Chromatin Assembly and Disassembly / Neoplastic Cells, Circulating Type of study: Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Cancer Lett Year: 2021 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Chromatin / Proto-Oncogene Proteins p21(ras) / Drug Resistance, Neoplasm / Chromatin Assembly and Disassembly / Neoplastic Cells, Circulating Type of study: Prognostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: Cancer Lett Year: 2021 Type: Article Affiliation country: China