Proteomic signature of the Dravet syndrome in the genetic Scn1a-A1783V mouse model.

Miljanovic, Nina; Hauck, Stefanie M; van Dijk, R Maarten; Di Liberto, Valentina; Rezaei, Ali; Potschka, Heidrun

Miljanovic, Nina; Hauck, Stefanie M; van Dijk, R Maarten; Di Liberto, Valentina; Rezaei, Ali; Potschka, Heidrun.

Affiliation

Miljanovic N; Institute of Pharmacology, Toxicology & Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians-University (LMU), Munich, Germany.
Hauck SM; Research Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Germany.
van Dijk RM; Institute of Pharmacology, Toxicology & Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.
Di Liberto V; Institute of Pharmacology, Toxicology & Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.
Rezaei A; Institute of Pharmacology, Toxicology & Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians-University (LMU), Munich, Germany.
Potschka H; Institute of Pharmacology, Toxicology & Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany. Electronic address: potschka@pharmtox.vetmed.uni-muenchen.de.

Neurobiol Dis ; 157: 105423, 2021 09.

Article in En | MEDLINE | ID: mdl-34144125

Subject(s)

Epilepsies, Myoclonic/metabolism; Hippocampus/metabolism; Proteomics; 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism; Carbon-Nitrogen Ligases/metabolism; Chromatography, Liquid; Disease Models, Animal; Disease Progression; Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism; Elevated Plus Maze Test; Epilepsies, Myoclonic/genetics; Epilepsies, Myoclonic/physiopathology; Female; Gene Knock-In Techniques; Gliosis; Haploinsufficiency; Hyperthermia/physiopathology; Immunohistochemistry; Male; Mice; NAV1.1 Voltage-Gated Sodium Channel/genetics; Neovascularization, Physiologic; Neuronal Plasticity; Nitric Oxide; Open Field Test; Rotarod Performance Test; Signal Transduction; Social Behavior; Synaptic Transmission; Tandem Mass Spectrometry; Vascular Endothelial Growth Factor Receptor-2/metabolism; ras-GRF1/metabolism

Key words

Epileptic encephalopathy; Genetic epilepsy; Mice; Proteome; Scn1a

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epilepsies, Myoclonic / Proteomics / Hippocampus Type of study: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2021 Type: Article Affiliation country: Germany

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