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Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain.
Muratspahic, Edin; Tomasevic, Natasa; Koehbach, Johannes; Duerrauer, Leopold; Hadzic, Seid; Castro, Joel; Schober, Gudrun; Sideromenos, Spyridon; Clark, Richard J; Brierley, Stuart M; Craik, David J; Gruber, Christian W.
Affiliation
  • Muratspahic E; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
  • Tomasevic N; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
  • Koehbach J; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Duerrauer L; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
  • Hadzic S; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia.
  • Castro J; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
  • Schober G; Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia 5042, Australia.
  • Sideromenos S; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.
  • Clark RJ; Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia 5042, Australia.
  • Brierley SM; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia 5000, Australia.
  • Craik DJ; Center for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, 1090 Vienna, Austria.
  • Gruber CW; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia.
J Med Chem ; 64(13): 9042-9055, 2021 07 08.
Article in En | MEDLINE | ID: mdl-34162205
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Plant Extracts / Abdominal Pain / Receptors, Opioid, kappa / Analgesics Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Type: Article Affiliation country: Austria
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Plant Extracts / Abdominal Pain / Receptors, Opioid, kappa / Analgesics Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Type: Article Affiliation country: Austria