Heteromerization between &#945;<sub>2A</sub> adrenoceptors and different polymorphic variants of the dopamine D<sub>4</sub> receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.

Casadó-Anguera, Verònica; Moreno, Estefanía; Sánchez-Soto, Marta; Cai, Ning Sheng; Bonaventura, Jordi; Homar-Ruano, Patricia; Rubinstein, Marcelo; Cortés, Antoni; Canela, Enric I; Ferré, Sergi; Casadó, Vicent

Heteromerization between α_2A adrenoceptors and different polymorphic variants of the dopamine D₄ receptor determines pharmacological and functional differences. Implications for impulsive-control disorders.

Casadó-Anguera, Verònica; Moreno, Estefanía; Sánchez-Soto, Marta; Cai, Ning Sheng; Bonaventura, Jordi; Homar-Ruano, Patricia; Rubinstein, Marcelo; Cortés, Antoni; Canela, Enric I; Ferré, Sergi; Casadó, Vicent.

Affiliation

Casadó-Anguera V; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.
Moreno E; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.
Sánchez-Soto M; Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, United States.
Cai NS; Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, United States.
Bonaventura J; Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, United States; Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse, Intramural Research Program, Baltimore, United
Homar-Ruano P; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.
Rubinstein M; Institute of Investigation in Genetic Engineering and Molecular Biology, Buenos Aires, Argentina.
Cortés A; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.
Canela EI; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain.
Ferré S; Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, United States. Electronic address: sferre@intra.nida.nih.gov.
Casadó V; Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona, Spain. Electronic address: vcasado@ub.edu.

Pharmacol Res ; 170: 105745, 2021 08.

Article in En | MEDLINE | ID: mdl-34182128

Subject(s)

Attention Deficit Disorder with Hyperactivity/metabolism; Cerebral Cortex/metabolism; Receptors, Adrenergic, alpha-2/metabolism; Receptors, Dopamine D4/metabolism; Animals; Attention Deficit Disorder with Hyperactivity/genetics; Attention Deficit Disorder with Hyperactivity/psychology; Cerebral Cortex/drug effects; Dopamine Agonists/pharmacology; Female; HEK293 Cells; Humans; Impulsive Behavior; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Polymorphism, Genetic; Protein Binding; Receptors, Adrenergic, alpha-2/genetics; Receptors, Dopamine D4/agonists; Receptors, Dopamine D4/genetics; Sheep, Domestic; Signal Transduction

Key words

870 trihydrochloride (PubChem CID: 49759035); A-412997 dihydrochloride (PubChem CID: 90488953); ADHD; BRL44408 maleate (PubChem CID: 10382026); Cerebral cortex; Clonidine hydrochloride (PubChem CID: 20179); Dexmedetomidine hydrochloride (PubChem CID: 6918081); Dopamine D(4) receptor; GPCR; Guanfacine hydrochloride (PubChem CID: 71401); L-745; Pramipexole dihydrochloride (PubChem CID: 119569); RX821002 hydrochloride (PubChem CID: 11957683); Receptor heteromer; Ropinirole (PubChem CID: 5095); Rotigotine hydrochloride (PubChem CID: 180335); α(2A) adrenoceptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Attention Deficit Disorder with Hyperactivity / Cerebral Cortex / Receptors, Adrenergic, alpha-2 / Receptors, Dopamine D4 Limits: Animals / Female / Humans / Male Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2021 Type: Article Affiliation country: Spain

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